I know this isn't your issue, but I'm posting in case you have some insight into the problem.
All of the sudden, the site became inoperative with these errors in the JS console
Refused to execute script from '<URL>' because its MIME type ('') is not executable, and strict MIME type checking is enabled.
Looking through Joomla fora, I found that this could be related to the following .htaccess construct
## Reduce MIME type security risks
<IfModule mod_headers.c>
Header set X-Content-Type-Options "nosniff"
</IfModule>
And, indeed, commenting it out fixed the problem (as did disabling Reduce MIME type security risks in Admin Tools).
It's hard to understand, as this has worked until now, and it works on a test site which is a subdomain of the live site where it was failing.
As I said, this is clearly not your problem, but if you have any insight it would be appreciated.